Cocoon Bioscience is launching its first enzyme product, Thermostable Inorganic Pyrophosphatase. This product leads the market in terms of efficiency and cost-effectiveness, as well as offering scalable production, thanks to Cocoon Bioscience’s powerful and unique expression system.  

With this release, we are making this highly valuable and applicable enzyme more readily accessible. This will overcome longstanding supply chain bottlenecks and empower research and development for the pharmaceutical and diagnostic industry, biological companies, and academic researchers.

Order now

Breaking down supply chain barriers

Since Covid-19, the interest in mRNA research has increased exponentially. Its full potential still hasn’t been uncovered.  

However, many of the enzymes used for in-vitro transcription (IVT) for mRNA are complex in nature and require highly specialized manufacturing processes. As a result, it’s costly to produce at R&D and manufacturing scales. This inevitably creates an expensive final product, which represents a significant barrier to the progress of important life sciences development.  

Cocoon Bioscience’s unique expression system, CrisBio®, overcomes this supply chain challenge. Using insect cocoons instead of heavily engineered and resource-intensive bioreactors, we simplify the production of critical enzymes.  

The result is a Thermostable Inorganic Pyrosphosphatase (TIPP) enzyme product that:  

• Is more affordable than market alternatives for the same level of activity. 

• Can be scaled from milligrams to large batches with just a couple of weeks’ notice. 

• Is accessible and achieves high standards of quality. 

Advancing life sciences applications for thermostable inorganic pyrophosphatase 

This product has a wide range of uses throughout life sciences and biotechnology. Some include RNA and gene synthesis, DNA polymerization reactions, and the hydrolysis of inorganic pyrophosphatase (PPi) for example.  

In particular, the thermostable inorganic form of pyrophosphatase offers several benefits. For example, it helps to maintain stability at high temperatures while also catalyzing reactions during the hydrolysis of PPi. It removes contaminant PPi in reagents used for SNP genotyping and prevents the accumulation of byproducts in gene synthesis. 

It also improves the efficiency, integrity, quality and yields of mRNA production through IVT, by: 

• Preventing pyrophosphatase inhibition 

• Enhancing RNA polymerase activity 

• Ensuring complete transcription 

• Maintaining stability at high temperatures 

Ultimately, this product enables many advancements for real-world applications, from the improvement of PCR reactions to enhancing biofuel production. By bringing a high-quality TIPP product to market at more competitive prices, we can help accelerate these advancements. In fact, we aim to develop an entire IVT mRNA portfolio.  

Beyond this current focus of development, we are committed to breaking down supply chain barriers for other recombinant enzymes used in research and industry. Since Cocoon Bioscience’s inception we have had a clear vision about the impact that our technology could have within life sciences applications. 

We are driven by innovation, sustainability and affordability. Our innovative expression system offers unparalleled performance compared to traditional systems in this type of enzyme production. Plus, our ‘back to basics’ principle minimizes machine and human involvement in our manufacturing process, resulting in low energy consumption and high efficiency. 

Not only does this make enzyme products more accessible, but also more sustainable for the future of the industry.  

An IVT mRNA portfolio 

We will continue to build onto our platform with new products related to the markets of mRNA expression and gene sequencing. Our team is developing an accessible portfolio for IVT mRNA expression, with pyrophosphatase as the flagship enzyme product. 

We expect to release more enzyme products for this portfolio in 2025, so stay tuned on our blog and LinkedIn to get updates.